Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy efficacy in melanoma by promoting an inflamed TME
Juliano Tiburcio de Freitas, Varsha Thakur, Kathryn M LaPorte, Vijay S Thakur, Brian Flores, Valentina Caicedo, Chioma G E Ajaegbu, Giuseppe Ingrasci, Zoe M Lipman, Keman Zhang, Hong Qiu, Thomas R Malek, Barbara Bedogni · 2024
Read Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy efficacy in melanoma by promoting an inflamed TME by Juliano Tiburcio de Freitas, Varsha Thakur, Kathryn M LaPorte, Vijay S Thakur, Brian Flores, Valentina Caicedo, Chioma G E Ajaegbu, Giuseppe Ingrasci, Zoe M Lipman, Keman Zhang, Hong Qiu, Thomas R Malek, Barbara Bedogni (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11533310.txt.
Description
De Freitas and co-authors test a new antibody that blocks the Notch1 signal in melanoma, in a 2024 cancer study. Skin melanoma often resists immune checkpoint drugs, and earlier work tied Notch1 to tumors that shut immune cells out. The team built an antibody that stops Notch1 from being switched on by its partner proteins. They tested it alone and with checkpoint therapy in human and mouse melanoma models.
The antibody cut Notch1 activation and slowed tumor growth in mice at a set dose. Tumors became more inflamed, meaning immune cells moved in more freely. That shift made checkpoint drugs work better than before. The findings suggest that blocking a single growth signal can warm up a cold tumor and widen the reach of immune therapy.
Catalog record
| CREATOR | Juliano Tiburcio de Freitas, Varsha Thakur, Kathryn M LaPorte, Vijay S Thakur, Brian Flores, Valentina Caicedo, Chioma G E Ajaegbu, Giuseppe Ingrasci, Zoe M Lipman, Keman Zhang, Hong Qiu, Thomas R Malek, Barbara Bedogni |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |