Roles of DNMT3B and PARP1 Genes Expression in Cytogenetically Normal Acute Myeloid Leukemia
Hager A Mahmoud, Shahira KA Botros, Abdelhamid Mohamed Fouad, Mahmoud M Kamel, Rania S Abdel Aziz · 2024
Read Roles of DNMT3B and PARP1 Genes Expression in Cytogenetically Normal Acute Myeloid Leukemia by Hager A Mahmoud, Shahira KA Botros, Abdelhamid Mohamed Fouad, Mahmoud M Kamel, Rania S Abdel Aziz (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11533204.txt.
Description
Hager Mahmoud and co-authors test two gene signals in a leukemia subtype in a 2024 study. Acute myeloid leukemia varies hugely in course and response, even when chromosome tests look normal. One gene, DNMT3B, writes chemical marks on DNA, while PARP1 helps repair damage and control cell fate.
Egyptian patients with normal chromosomes gave samples alongside healthy controls. Gene activity levels were set against lab traits, treatment response, and survival. Both genes are known cancer players in other settings, so their joint role here was open. A cheap gene read that forecasts response could steer drug choice early. Regional data also matter, since most gene studies draw on other populations.
Catalog record
| CREATOR | Hager A Mahmoud, Shahira KA Botros, Abdelhamid Mohamed Fouad, Mahmoud M Kamel, Rania S Abdel Aziz |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |