16S rRNA methyltransferase KsgA contributes to oxidative stress and antibiotic resistance in Pseudomonas aeruginosa
Kamonwan Phatinuwat, Sopapan Atichartpongkul, Watthanachai Jumpathong, Skorn Mongkolsuk, Mayuree Fuangthong · 2024
Read 16S rRNA methyltransferase KsgA contributes to oxidative stress and antibiotic resistance in Pseudomonas aeruginosa by Kamonwan Phatinuwat, Sopapan Atichartpongkul, Watthanachai Jumpathong, Skorn Mongkolsuk, Mayuree Fuangthong (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11532479.txt.
Description
A small enzyme that stamps two methyl marks on the ribosome's RNA turns out to matter for how a tough bacterium handles stress and antibiotics. Kamonwan Phatinuwat and four co-authors delete the ksgA gene in Pseudomonas aeruginosa and compare the mutant with normal cells across a wide panel of chemicals.
Without the marks, the bacteria grew more sensitive to a superoxide generator, partly because a protective enzyme's protein level fell even though its gene message did not. The mutant also became sensitive to two antibiotics, tied to lower levels of elongation factor genes, yet oddly resistant to kasugamycin. The authors say the work ties a conserved RNA modification to stress defense and drug response. The study appears in 2024.
Catalog record
| CREATOR | Kamonwan Phatinuwat, Sopapan Atichartpongkul, Watthanachai Jumpathong, Skorn Mongkolsuk, Mayuree Fuangthong |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |