VCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN
Shijiang Wang, Jiangbo Nie, Haoxin Jiang, Anan Li, Nanshan Zhong, Weilai Tong, Geliang Yao, Alan Jiang, Xinsheng Xie, Yanxin Zhong, Zhiguo Shu, Jiaming Liu, Feng Yang, Zhili Liu · 2024
Read VCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN by Shijiang Wang, Jiangbo Nie, Haoxin Jiang, Anan Li, Nanshan Zhong, Weilai Tong, Geliang Yao, Alan Jiang, Xinsheng Xie, Yanxin Zhong, Zhiguo Shu, Jiaming Liu, Feng Yang, Zhili Liu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11532476.txt.
Description
Shijiang Wang and thirteen co-authors find a protein team that shields a fat making enzyme and speeds bone cancer growth, in a 2024 journal article. The cancer is osteosarcoma, a fierce bone tumor of the young. Faulty self eating in cells, a cleanup act gone wrong, helps it grow.
The team saw the fat enzyme run high in cancer cells with the cleanup act switched on. It fed cell growth in a way that hung on that act. A second protein guards the enzyme: it calls in a third that clips off the tags that would send the enzyme to be broken down. Blocking the enzyme or its clipper curbed the boost from the guard. The trio is put forth as a drug target set.
Catalog record
| CREATOR | Shijiang Wang, Jiangbo Nie, Haoxin Jiang, Anan Li, Nanshan Zhong, Weilai Tong, Geliang Yao, Alan Jiang, Xinsheng Xie, Yanxin Zhong, Zhiguo Shu, Jiaming Liu, Feng Yang, Zhili Liu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |