Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair
Ichiro Aoki, Luca Golinelli, Eva Dunkel, Shripriya Bhat, Erschad Bassam, Isabel Beets, Alexander Gottschalk · 2024
Read Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair by Ichiro Aoki, Luca Golinelli, Eva Dunkel, Shripriya Bhat, Erschad Bassam, Isabel Beets, Alexander Gottschalk (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11532408.txt.
Description
One pair of nerve cells in the tiny worm Caenorhabditis elegans releases two peptide signals that pull behaviour in opposite directions. Ichiro Aoki and co-authors untangle how the pair stays in balance in their 2024 paper. The peptides, NLP-10 and FLP-1, both come from the AVK interneurons and act on the worm's crawling speed.
NLP-10 speeds the worm up through a receptor on premotor cells, and it also drives the worm's escape response to touch and harsh light. FLP-1 slows things down in a sneakier way: it feeds back onto AVK itself and cuts the release of NLP-10. The authors argue that such self-braking peptide loops may be a common trick nervous systems use to fine-tune behaviour.
Catalog record
| CREATOR | Ichiro Aoki, Luca Golinelli, Eva Dunkel, Shripriya Bhat, Erschad Bassam, Isabel Beets, Alexander Gottschalk |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |