The immune-modulatory role of MSCs exerted by PI3K/AKT signaling pathway in kidney tissue after cyclophosphamide
Heba M Saad Eldien, Mohammed Jayed Alenzi · 2023
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Description
Heba Saad Eldien and Mohammed Jayed Alenzi present a study from twenty twenty-three on how stem cells calm the kidney after a harsh immune drug. The drug, cyclophosphamide, damps the immune system but can harm the kidney. Rats were split in four groups: clean controls, drug alone, drug then rest, and drug then stem cells from marrow. Kidneys were read at set days.
The drug raised immune cell marks and a cell death switch in the kidney. Both rest and stem cells pulled those marks down. The drug also cut a growth path, PI3K and AKT, which both groups restored. Stem cell rats gained most in guard and growth factors. The team credits the path for the calming effect.
Catalog record
| CREATOR | Heba M Saad Eldien, Mohammed Jayed Alenzi |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |