Research progress of natural active compounds on improving podocyte function to reduce proteinuria in diabetic kidney disease
Le Gong, Rui Wang, Xinyu Wang, Jing Liu, Zhaodi Han, Qian Li, Yi Jin, Hui Liao · 2023
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Description
Le Gong and seven co-authors review natural compounds that protect the kidney's filter cells in diabetic kidney disease, in a paper from 2023. Damage to those cells, called podocytes, lets protein leak into urine, a key sign of the disease. The review sorts the disease's five stages and the jobs of thirteen podocyte proteins, then sums up fifteen natural compounds.
Lab and animal work shows the compounds ease inflammation, oxidative stress, and cell death through several known pathways. Two filter proteins, nephrin and podocin, were the most studied targets. The authors map which compound acts through which pathway to guide later drug work.
Catalog record
| CREATOR | Le Gong, Rui Wang, Xinyu Wang, Jing Liu, Zhaodi Han, Qian Li, Yi Jin, Hui Liao |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |