Rapid quantification of 50 fatty acids in small amounts of biological samples for population molecular phenotyping
Pinghui Liu, Qinsheng Chen, Lianglong Zhang, Chengcheng Ren, Biru Shi, Jingxian Zhang, Shuaiyao Wang, Ziliang Chen, Qi Wang, Hui Xie, Qingxia Huang, Huiru Tang · 2023
Read Rapid quantification of 50 fatty acids in small amounts of biological samples for population molecular phenotyping by Pinghui Liu, Qinsheng Chen, Lianglong Zhang, Chengcheng Ren, Biru Shi, Jingxian Zhang, Shuaiyao Wang, Ziliang Chen, Qi Wang, Hui Xie, Qingxia Huang, Huiru Tang (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10960574.txt.
Description
Pinghui Liu, Huiru Tang, and colleagues deliver a method that measures fifty fatty acids in a drop of sample within eight minutes. Fatty acid profiles phenotype whole populations for physiology and disease research, but existing methods are slow. Their gas chromatography pipeline converts every lipid class into measurable esters in one step.
Precision, stability, and linearity held across wide concentration ranges and many sample types, from urine and plasma to animal tissues. A computed retention index, anchored to the sample's own molecules rather than added standards, cut batch-to-batch drift to seconds, making cross-study comparison feasible. The authors offer the system as cheap, high-throughput infrastructure for cohort-scale molecular phenotyping.
Catalog record
| CREATOR | Pinghui Liu, Qinsheng Chen, Lianglong Zhang, Chengcheng Ren, Biru Shi, Jingxian Zhang, Shuaiyao Wang, Ziliang Chen, Qi Wang, Hui Xie, Qingxia Huang, Huiru Tang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |