Identification of FLRT2 as a key prognostic gene through a comprehensive analysis of TMB and IRGPs in BLCA patients
Yaling Tao, Xiaoling Yu, Huaiwei Cong, Jinpeng Li, Junqi Zhu, Huaxin Ding, Qian Chen, Ting Cai · 2024
Read Identification of FLRT2 as a key prognostic gene through a comprehensive analysis of TMB and IRGPs in BLCA patients by Yaling Tao, Xiaoling Yu, Huaiwei Cong, Jinpeng Li, Junqi Zhu, Huaxin Ding, Qian Chen, Ting Cai (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10937436.txt.
Description
Yaling Tao and co-authors hunted for a gene that predicts outlook in bladder cancer in a 2023 study. The tumor's immune setting and immune-linked genes shape how the cancer grows and how patients fare. The team wanted genes that carry real prognostic weight and clues to how they act.
They compared gene activity between tumors with high and low counts of mutations, then layered in immune-related gene sets. One gene, FLRT2, emerged as a key marker tied to patient outcomes. Follow-up analysis explored its links to immune behavior in the tumor. A validated marker could help sort patients for closer watch or added therapy, and it names a target for deeper study.
Catalog record
| CREATOR | Yaling Tao, Xiaoling Yu, Huaiwei Cong, Jinpeng Li, Junqi Zhu, Huaxin Ding, Qian Chen, Ting Cai |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |