Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia
Victoria S Rashbrook, Laura Denti, Christiana Ruhrberg · 2023
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Description
Victoria Rashbrook, Laura Denti, and Christiana Ruhrberg report a drug safety problem in lab mice in a 2023 paper. Tamoxifen is widely used to switch genes on or off in engineered mice at chosen times. The team find that male mice given tamoxifen and then a common anesthetic mix suffered urinary plugs, illness, and death at high rates.
The anesthetic drug at fault is also sold in a stronger mirror form, which caused harm in male mice even without tamoxifen. The authors warn against using either form in male mice after tamoxifen, and urge care in picking anesthetics for such studies.
Catalog record
| CREATOR | Victoria S Rashbrook, Laura Denti, Christiana Ruhrberg |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |