The glucocorticoid dexamethasone inhibits HIF-1α stabilization and metabolic reprogramming in lipopolysaccharide-stimulated primary macrophages
Sally A Clayton, Chloe Lockwood, John D O’Neil, Kalbinder K Daley, Sofia Hain, Dina Abdelmottaleb, Oliwia O Bolimowska, Daniel A Tennant, Andrew R Clark · 2023
Read The glucocorticoid dexamethasone inhibits HIF-1α stabilization and metabolic reprogramming in lipopolysaccharide-stimulated primary macrophages by Sally A Clayton, Chloe Lockwood, John D O’Neil, Kalbinder K Daley, Sofia Hain, Dina Abdelmottaleb, Oliwia O Bolimowska, Daniel A Tennant, Andrew R Clark (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10917182.txt.
Description
Sally Clayton and eight co-authors study a steroid's effect on immune cell metabolism in a paper from two thousand twenty-three. Dexamethasone calms inflammation but disturbs blood sugar with long use. Macrophages, key targets of the drug, burn glucose fast when activated.
In mouse and human macrophages, a bacterial trigger normally boosts a factor that drives glucose uptake. Dexamethasone blocked that factor's buildup in both cell types, cutting expression of the glucose transporter. Other metabolic effects split between the species. The authors argue the drug's benefit and its sugar side effects may share one root: reduced glucose use in activated immune cells. The finding reframes how steroid side effects might be separated from their benefits.
Catalog record
| CREATOR | Sally A Clayton, Chloe Lockwood, John D O’Neil, Kalbinder K Daley, Sofia Hain, Dina Abdelmottaleb, Oliwia O Bolimowska, Daniel A Tennant, Andrew R Clark |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |