Genome editing and molecular analyses of an Arabidopsis transcription factor, LATE FLOWERING
Yoshimi Nakano, Maki Kawai, Moeca Arai, Sumire Fujiwara · 2023
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Description
Yoshimi Nakano and three co-authors probe the LATE FLOWERING gene in Arabidopsis in this 2023 paper. Extra copies of this gene delay flowering, partly by muting the gene that makes florigen, the flower signal. The protein carries a known repression motif, so it was assumed to be a repressor, but proof was thin. The team edited the gene out. Surprisingly, the mutants flowered normally, which points to backup factors covering its loss. Assays confirmed the protein does repress gene activity, through both its motif and other regions.
Two partners emerged. The motif binds a general corepressor called TOPLESS. A separate region binds CRABS CLAW, a regulator that tells flower tissue when to stop growing. The authors suggest the two form a repression team for that timing job. The work explains why removing one gene shows nothing: partners and backups share the load.
Catalog record
| CREATOR | Yoshimi Nakano, Maki Kawai, Moeca Arai, Sumire Fujiwara |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |