Tick bite-induced alpha-gal syndrome and immunologic responses in an alpha-gal deficient murine model
Surendra Raj Sharma, Shailesh K. Choudhary, Julia Vorobiov, Scott P. Commins, Shahid Karim · 2024
Read Tick bite-induced alpha-gal syndrome and immunologic responses in an alpha-gal deficient murine model by Surendra Raj Sharma, Shailesh K. Choudhary, Julia Vorobiov, Scott P. Commins, Shahid Karim (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10882631.txt.
Description
Surendra Sharma, Shailesh Choudhary, and Julia Vorobiov lead a team reproducing tick-bite meat allergy in mice engineered to lack the sugar at its center. Their study was published in two thousand twenty-three. The syndrome makes people allergic to red meat hours after eating it. Tick bites are the suspected sensitizer.
Mice lacking the alpha-gal sugar were bitten by two tick species, then fed pork. Lone star tick bites raised allergy-linked antibodies far more than gulf coast tick bites. Pork challenge dropped the lone-star group's body temperature, an allergy sign. Bite-site skin showed its own immune gene patterns. The model separates the two ticks' roles cleanly. It also gives researchers a living system for mechanism hunting. Why one tick sensitizes and the other barely does is the open question. Prevention ideas can now be tested before human studies.
Catalog record
| CREATOR | Surendra Raj Sharma, Shailesh K. Choudhary, Julia Vorobiov, Scott P. Commins, Shahid Karim |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |