Male histone deacetylase 6 (HDAC6) knockout mice have enhanced ventilatory responses to hypoxic challenge
Paulina M. Getsy, Gregory A. Coffee, Thomas J. Kelley, Stephen J. Lewis · 2024
Read Male histone deacetylase 6 (HDAC6) knockout mice have enhanced ventilatory responses to hypoxic challenge by Paulina M. Getsy, Gregory A. Coffee, Thomas J. Kelley, Stephen J. Lewis (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10880035.txt.
Description
Breathing harder when oxygen runs low is a reflex with deep control circuitry, and one gene that trims proteins may sit inside that circuit. Paulina Getsy and co-authors tested male mice lacking the gene, HDAC6, in a 2023 study. The mice breathed a low-oxygen mix for fifteen minutes while the team recorded their breathing in fine detail.
Even at rest, the knockout mice breathed differently from normal mice. During the low-oxygen challenge, their responses ran stronger across nearly every measure, from breathing rate to the force of each breath. Their recovery on room air also diverged sharply. The authors conclude the gene plays a fundamental part in setting how mice answer low oxygen.
Catalog record
| CREATOR | Paulina M. Getsy, Gregory A. Coffee, Thomas J. Kelley, Stephen J. Lewis |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |