Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination
Ariel M. Lyons-Warren, Evelyne K. Tantry, Elizabeth H. Moss, Mikhail Y. Kochukov, Benjamin D.W. Belfort, Joshua Ortiz-Guzman, Zachary Freyberg, Benjamin R. Arenkiel · 2023
Read Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination by Ariel M. Lyons-Warren, Evelyne K. Tantry, Elizabeth H. Moss, Mikhail Y. Kochukov, Benjamin D.W. Belfort, Joshua Ortiz-Guzman, Zachary Freyberg, Benjamin R. Arenkiel (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10872518.txt.
Description
Ariel Lyons-Warren and seven co-authors split a double signal in the mouse nose-brain in a 2023 paper. A class of interneurons in the olfactory bulb releases two messengers at once, dopamine and the inhibitory GABA. Co-release enriches signaling, but which messenger does what in smell was unknown.
Using intersectional genetics, the team blocked just one messenger at a time from those cells and watched the circuit and the animal. Anatomy and physiology showed the two messengers reach different downstream targets. Each shapes the firing patterns of the bulb's output neurons in its own way. Behavior tests tied each messenger to distinct parts of smell performance, detecting odors versus telling them apart. The study turns a curiosity of cell biology into circuit logic: one neuron, two messages, two jobs. The approach generalizes to other brain areas where co-release is common.
Catalog record
| CREATOR | Ariel M. Lyons-Warren, Evelyne K. Tantry, Elizabeth H. Moss, Mikhail Y. Kochukov, Benjamin D.W. Belfort, Joshua Ortiz-Guzman, Zachary Freyberg, Benjamin R. Arenkiel |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |