A hope for ineffective antibiotics to return to treatment: investigating the anti-biofilm potential of melittin alone and in combination with penicillin and oxacillin against multidrug resistant-MRSA and -VRSA
Saba Jalalifar, Shabnam Razavi, Rasoul Mirzaei, Gholamreza Irajian, Kamran Pooshang Bagheri · 2024
Read A hope for ineffective antibiotics to return to treatment: investigating the anti-biofilm potential of melittin alone and in combination with penicillin and oxacillin against multidrug resistant-MRSA and -VRSA by Saba Jalalifar, Shabnam Razavi, Rasoul Mirzaei, Gholamreza Irajian, Kamran Pooshang Bagheri (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10870424.txt.
Description
Saba Jalalifar and co-authors offer a 2023 lab study testing a bee venom peptide against drug-resistant staph bacteria. Resistant strains shrug off once-reliable antibiotics and hide inside tough biofilms. Peptides that kill microbes may restore the old drugs' lost power.
Melittin, the main peptide in bee venom, was tested alone and paired with penicillin or oxacillin. Targets were resistant strains that form biofilms, including vancomycin-resistant ones. Lab assays measured bacterial killing and biofilm breakup at several doses. Pairing a peptide with failed antibiotics is the core hope here: reviving cheap, well-known drugs against infections that now outlast them.
Catalog record
| CREATOR | Saba Jalalifar, Shabnam Razavi, Rasoul Mirzaei, Gholamreza Irajian, Kamran Pooshang Bagheri |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |