Chronic hypoxia disrupts T regulatory cell phenotype contributing to the emergence of exTreg-TH17 cells
Benjamin J. Lantz, Mika Moriwaki, Olufunmilola M. Oyebamiji, Yan Guo, Laura Gonzalez Bosc · 2024
Read Chronic hypoxia disrupts T regulatory cell phenotype contributing to the emergence of exTreg-TH17 cells by Benjamin J. Lantz, Mika Moriwaki, Olufunmilola M. Oyebamiji, Yan Guo, Laura Gonzalez Bosc (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10859758.txt.
Description
Benjamin Lantz and co-authors study low oxygen and immune cells in mice in a 2023 paper, per its head. A balance sits between attack ready T cells and calm regulatory T cells. When that balance tips, lung blood pressure can rise.
Mice kept in low oxygen grew more attack cells in the lungs, with no rise in calm cells. Gene reads showed some calm cells had switched sides and joined the attack type. That switch may explain why calm cells fail to stop the lung harm on their own. The work points at cell switching as a step in this form of lung disease.
Catalog record
| CREATOR | Benjamin J. Lantz, Mika Moriwaki, Olufunmilola M. Oyebamiji, Yan Guo, Laura Gonzalez Bosc |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |