The ‘analysis of gene expression and biomarkers for point-of-care decision support in Sepsis‘ study; temporal clinical parameter analysis and validation of early diagnostic biomarker signatures for severe inflammation andsepsis-SIRS discrimination
Tamas Szakmany, Eleanor Fitzgerald, Harriet N. Garlant, Tony Whitehouse, Tamas Molnar, Sanjoy Shah, Dong Ling Tong, Judith E. Hall, Graham R. Ball, Karen E. Kempsell · 2024
Read The ‘analysis of gene expression and biomarkers for point-of-care decision support in Sepsis‘ study; temporal clinical parameter analysis and validation of early diagnostic biomarker signatures for severe inflammation andsepsis-SIRS discrimination by Tamas Szakmany, Eleanor Fitzgerald, Harriet N. Garlant, Tony Whitehouse, Tamas Molnar, Sanjoy Shah, Dong Ling Tong, Judith E. Hall, Graham R. Ball, Karen E. Kempsell (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10850284.txt.
Description
Tamas Szakmany and a large team of co-authors published this sepsis study in 2023. Telling sepsis, a life-threatening response to infection, apart from sterile inflammation is a daily problem in intensive care, and slow answers cost lives. The team hunted for gene signals in blood cells that flag severe inflammation and separate the two states. They recruited intensive care patients across several United Kingdom hospitals, including abdominal and lung sepsis cases and cardiac arrest patients with sterile inflammation, plus healthy donors.
Nineteen strongly changed genes marked severe inflammation from either cause, and a two-gene signature classified it almost perfectly in their data. A second signature of five genes separated sepsis from sterile inflammation with high accuracy. The authors note the signatures performed unevenly on outside datasets, possibly due to platform differences. The work aims at a point-of-care test that speeds the first treatment decision.
Catalog record
| CREATOR | Tamas Szakmany, Eleanor Fitzgerald, Harriet N. Garlant, Tony Whitehouse, Tamas Molnar, Sanjoy Shah, Dong Ling Tong, Judith E. Hall, Graham R. Ball, Karen E. Kempsell |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |