Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity
Spencer Greatorex, Supreet Kaur, Chrysovalantou E. Xirouchaki, Pei K. Goh, Florian Wiede, Amanda J. Genders, Melanie Tran, YaoYao Jia, Arthe Raajendiran, Wendy A. Brown, Catriona A. McLean, Junichi Sadoshima, Matthew J. Watt, Tony Tiganis · 2024
Read Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity by Spencer Greatorex, Supreet Kaur, Chrysovalantou E. Xirouchaki, Pei K. Goh, Florian Wiede, Amanda J. Genders, Melanie Tran, YaoYao Jia, Arthe Raajendiran, Wendy A. Brown, Catriona A. McLean, Junichi Sadoshima, Matthew J. Watt, Tony Tiganis (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10849767.txt.
Description
Spencer Greatorex and co-authors report a study, given in the head as a 2023 paper, on a self-guard loop that slows fatty liver disease in obesity. Most people with obesity get a fatty liver, but only some go on to the inflamed, scarred form that harms health. What holds the line for the rest was not clear.
The team found two partners in liver cells that rise early in the disease and work as a pair. One makes a mild oxidant that switches on the other, a master guard that lifts cell defences, which in turn makes more of the first. Cutting the first partner in mouse liver cells weakened the guard and let damage grow. Mice with it cut, fed a high fat diet, went on to the inflamed form. Boosting it held the disease back.
Catalog record
| CREATOR | Spencer Greatorex, Supreet Kaur, Chrysovalantou E. Xirouchaki, Pei K. Goh, Florian Wiede, Amanda J. Genders, Melanie Tran, YaoYao Jia, Arthe Raajendiran, Wendy A. Brown, Catriona A. McLean, Junichi Sadoshima, Matthew J. Watt, Tony Tiganis |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |