Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice
Jianrui Song, Yanling Zhang, Ryan A Frieler, Anthony Andren, Sherri Wood, Daniel J Tyrrell, Peter Sajjakulnukit, Jane C Deng, Costas A Lyssiotis, Richard M Mortensen, Morgan Salmon, Daniel R Goldstein · 2024
Read Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice by Jianrui Song, Yanling Zhang, Ryan A Frieler, Anthony Andren, Sherri Wood, Daniel J Tyrrell, Peter Sajjakulnukit, Jane C Deng, Costas A Lyssiotis, Richard M Mortensen, Morgan Salmon, Daniel R Goldstein (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10849764.txt.
Description
Song and co-authors test in a study dated 2023 in its head whether a natural compound called itaconate can slow artery clogging. The compound is made by immune cells and calms inflammation. In mice, both the compound and the enzyme that makes it rose as artery disease grew, and mice lacking the enzyme fared worse.
Levels of the enzyme also ran low in clogged human artery samples. A form of the compound eased disease in mice fed a rich diet. Its effect needed a switch that turns on cell defense, called Nrf2. Turning this path on may be a new route to treat artery disease.
Catalog record
| CREATOR | Jianrui Song, Yanling Zhang, Ryan A Frieler, Anthony Andren, Sherri Wood, Daniel J Tyrrell, Peter Sajjakulnukit, Jane C Deng, Costas A Lyssiotis, Richard M Mortensen, Morgan Salmon, Daniel R Goldstein |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |