Prescription trend and lactic acidosis in patients prescribed metformin before and after the revision of package insert for allowing metformin administration to patients with moderately decreased kidney function based on real-world data from MID-NET® in Japan
Takashi Waki, Yusuke Okada, Yuki Kinoshita, Kazuhiro Kajiyama, Chieko Ishiguro, Yuki Nakazato, Ryota Kimura, Harumi Maniwa, Naoya Horiuchi, Toyotaka Iguchi, Yoshiaki Uyama · 2024
Read Prescription trend and lactic acidosis in patients prescribed metformin before and after the revision of package insert for allowing metformin administration to patients with moderately decreased kidney function based on real-world data from MID-NET® in Japan by Takashi Waki, Yusuke Okada, Yuki Kinoshita, Kazuhiro Kajiyama, Chieko Ishiguro, Yuki Nakazato, Ryota Kimura, Harumi Maniwa, Naoya Horiuchi, Toyotaka Iguchi, Yoshiaki Uyama (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10847222.txt.
Description
Takashi Waki and co-authors track metformin use in Japan after a label change in a study whose text is dated 2023. Metformin is a first-line diabetes drug, but it carries a rare risk of lactic acid build-up in people with weak kidneys. In June 2019 Japan revised the package insert to allow use in patients with moderately reduced kidney function.
Using a national medical database, the team compared new users before and after the change, about 5,874 patients in all. Prescribing volume barely shifted, but the starting daily dose dropped after the revision. Fewer than ten cases of lactic acidosis appeared in either period, and none at all in the moderate kidney group. The data support the safety of the wider allowance.
Catalog record
| CREATOR | Takashi Waki, Yusuke Okada, Yuki Kinoshita, Kazuhiro Kajiyama, Chieko Ishiguro, Yuki Nakazato, Ryota Kimura, Harumi Maniwa, Naoya Horiuchi, Toyotaka Iguchi, Yoshiaki Uyama |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |