Efficient delivery of the immunodominant genes of African swine fever virus by adeno-associated virus serotype 2
Rustam Ravilov, Antonina Galeeva, Gennadiy Frolov, Marina Efimova, Elena Zakirova, Albert Rizvanov, Almaz Hisamutdinov, Lenar Garipov, Danil Mingaleev · 2023
Read Efficient delivery of the immunodominant genes of African swine fever virus by adeno-associated virus serotype 2 by Rustam Ravilov, Antonina Galeeva, Gennadiy Frolov, Marina Efimova, Elena Zakirova, Albert Rizvanov, Almaz Hisamutdinov, Lenar Garipov, Danil Mingaleev (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10844788.txt.
Description
Rustam Ravilov, Antonina Galeeva, and their co-authors built gene delivery packages aimed at a future vaccine against African swine fever. Their 2023 study uses a harmless carrier virus, AAV2, to carry key genes of the swine fever virus into cells. The disease is a major threat to pigs, and a working vaccine is still lacking.
Computer analysis picked four genes most likely to draw a strong immune response. The team placed each gene into the carrier and assembled the packages in cultured cells, then measured how much carrier was made. Tests in human and animal cells checked that the genes switched on, hit the right cells, and did not poison them. The work is an early lab step toward a vector based vaccine.
Catalog record
| CREATOR | Rustam Ravilov, Antonina Galeeva, Gennadiy Frolov, Marina Efimova, Elena Zakirova, Albert Rizvanov, Almaz Hisamutdinov, Lenar Garipov, Danil Mingaleev |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |