Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging
Patrick Treat Paine, Cheyenne Rechsteiner, Francesco Morandini, Gabriela Desdín-Micó, Calida Mrabti, Alberto Parras, Amin Haghani, Robert Brooke, Steve Horvath, Andrei Seluanov, Vera Gorbunova, Alejandro Ocampo · 2024
Read Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging by Patrick Treat Paine, Cheyenne Rechsteiner, Francesco Morandini, Gabriela Desdín-Micó, Calida Mrabti, Alberto Parras, Amin Haghani, Robert Brooke, Steve Horvath, Andrei Seluanov, Vera Gorbunova, Alejandro Ocampo (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10844398.txt.
Description
Patrick Treat Paine and co-authors test whether partly resetting cells can undo DNA damage in mice bred to age too fast. Their paper, dated 2023 in its own text, uses mice with a flaw in a gene called ERCC1. Cells that have aged lose their care in copying and repair, while stem cells keep it.
The team boosted the reset process by pairing small drug-like compounds with the classic reset factors. Damage in the mice fell back sharply, repair work in cells rose, and a clock that reads age from chemical marks on DNA was set back. Blocking two growth-signal paths with drugs copied some of the gains, which points to how the reset may heal cells.
Catalog record
| CREATOR | Patrick Treat Paine, Cheyenne Rechsteiner, Francesco Morandini, Gabriela Desdín-Micó, Calida Mrabti, Alberto Parras, Amin Haghani, Robert Brooke, Steve Horvath, Andrei Seluanov, Vera Gorbunova, Alejandro Ocampo |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |