Introducing Matrix Metalloproteinases as Crucial Targets for Intra-articular Laser Therapy in Patients with Synovial Fluid of Knee Osteoarthritis
Reza M Robati, Zahra Razzaghi, Babak Arjmand, Mostafa Rezaei Tavirani, Fatemeh Sheibani · 2023
Read Introducing Matrix Metalloproteinases as Crucial Targets for Intra-articular Laser Therapy in Patients with Synovial Fluid of Knee Osteoarthritis by Reza M Robati, Zahra Razzaghi, Babak Arjmand, Mostafa Rezaei Tavirani, Fatemeh Sheibani (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10843209.txt.
Description
Robati and co-authors use network analysis of joint fluid proteins to find what laser therapy changes in knee osteoarthritis. Many older people suffer this painful joint wear, and low level laser treatment is a candidate therapy with an unclear mechanism. Their 2023 study builds a protein interaction map from patient fluid data, then compares it with protein shifts reported after laser treatment.
Two proteins sat at the network's hub, one of them a tissue cutting enzyme called MMP2. Proteins changed by laser treatment plugged into the same network, and one inflammatory signal's activity fell. The authors conclude that dialing down MMP2 is the main event behind laser linked improvement. They propose such enzymes as targets for joint injected laser therapy.
Catalog record
| CREATOR | Reza M Robati, Zahra Razzaghi, Babak Arjmand, Mostafa Rezaei Tavirani, Fatemeh Sheibani |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |