Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid cancers
Wan Ching Lim, Maria Eugenia Marques Da Costa, Karine Godefroy, Eric Jacquet, Loren Gragert, Windy Rondof, Antonin Marchais, Naima Nhiri, Davide Dalfovo, Mathias Viard, Nizar Labaied, Asif M. Khan, Philippe Dessen, Alessandro Romanel, Claudia Pasqualini, Gudrun Schleiermacher, Mary Carrington, Laure · 2024
Read Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid cancers by Wan Ching Lim, Maria Eugenia Marques Da Costa, Karine Godefroy, Eric Jacquet, Loren Gragert, Windy Rondof, Antonin Marchais, Naima Nhiri, Davide Dalfovo, Mathias Viard, Nizar Labaied, Asif M. Khan, Philippe Dessen, Alessandro Romanel, Claudia Pasqualini, Gudrun Schleiermacher, Mary Carrington, Laure (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10839790.txt.
Description
Lim and co-authors chart how children's solid cancers dodge the immune tag system in work dated 2023 in the text. The HLA tags decide what the immune system can see, and their state in childhood cancers was barely mapped.
Gene reads from 576 young patients with stubborn solid tumors show wide tag variety, no narrowed pool, and few mutations in the tag machinery. Yet tumors often lost one copy of key tag genes, above all bone and brain cancers. Two tag genes and a peptide loader were commonly silenced. The map names escape routes that immunotherapy must outflank.
Catalog record
| CREATOR | Wan Ching Lim, Maria Eugenia Marques Da Costa, Karine Godefroy, Eric Jacquet, Loren Gragert, Windy Rondof, Antonin Marchais, Naima Nhiri, Davide Dalfovo, Mathias Viard, Nizar Labaied, Asif M. Khan, Philippe Dessen, Alessandro Romanel, Claudia Pasqualini, Gudrun Schleiermacher, Mary Carrington, Laure |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 91 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |