Improved overall survival in patients with high-grade serous ovarian cancer is associated with CD16a+ immunologic neighborhoods containing NK cells, T cells and macrophages
Sarah Nersesian, Riley J. Arseneau, Jorge P. Mejia, Stacey N. Lee, Lauren P. Westhaver, Nigel W. Griffiths, Stephanie R. Grantham, Liliane Meunier, Laudine Communal, Avik Mukherjee, Anne-Marie Mes-Masson, Thomas Arnason, Brad H. Nelson, Jeanette E. Boudreau · 2024
Read Improved overall survival in patients with high-grade serous ovarian cancer is associated with CD16a+ immunologic neighborhoods containing NK cells, T cells and macrophages by Sarah Nersesian, Riley J. Arseneau, Jorge P. Mejia, Stacey N. Lee, Lauren P. Westhaver, Nigel W. Griffiths, Stephanie R. Grantham, Liliane Meunier, Laudine Communal, Avik Mukherjee, Anne-Marie Mes-Masson, Thomas Arnason, Brad H. Nelson, Jeanette E. Boudreau (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10838965.txt.
Description
Sarah Nersesian and co-authors present a study whose head gives the year as 2023. The catalog lists it under 2024. High-grade serous ovarian cancer has seen flat survival for fifty years. Immune therapies have mostly failed against it despite tumors full of mutations and immune cells. The gap is in how immune neighborhoods inside the tumor actually work. The team analyzes paired tissue cores from 939 patients. Multiplex staining, digital pathology, and computation map the cells' locations.
Survival improves where neighborhoods carry a CD16a marker and mix natural killer cells, T cells, and macrophages. Spatial arrangement, not mere presence, carries the signal. Oncologists get a spatial clue for why immunotherapy stalls in this cancer. Neighborhood maps could sort patients for immune trials more wisely. The huge sample, nearly a thousand patients, gives the pattern weight that small cohorts cannot.
Catalog record
| CREATOR | Sarah Nersesian, Riley J. Arseneau, Jorge P. Mejia, Stacey N. Lee, Lauren P. Westhaver, Nigel W. Griffiths, Stephanie R. Grantham, Liliane Meunier, Laudine Communal, Avik Mukherjee, Anne-Marie Mes-Masson, Thomas Arnason, Brad H. Nelson, Jeanette E. Boudreau |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |