PTPN13 rs989902 and CHEK2 rs738722 are associated with esophageal cancer
Ruisha Tu, Dunjing Zhong, Ping Li, Yongyu Li, Zhuang Chen, Feixiang Hu, Guihong Yuan, Zhaowei Chen, Shuyong Yu, Jian Song · 2023
Read PTPN13 rs989902 and CHEK2 rs738722 are associated with esophageal cancer by Ruisha Tu, Dunjing Zhong, Ping Li, Yongyu Li, Zhuang Chen, Feixiang Hu, Guihong Yuan, Zhaowei Chen, Shuyong Yu, Jian Song (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10836260.txt.
Description
Ruisha Tu and co-authors test in 2023 whether two gene variants raise the risk of esophageal cancer. The squamous form of this cancer runs in families to a degree, and both genes, PTPN13 and CHEK2, are already tied to its development. The team compared patients and controls in the Chinese Han population.
One letter change in each gene came with higher risk, raising the odds by roughly a quarter. The links held across age, sex, smoking, and drinking groups. One variant also went with lower cancer stage, and the other with less spread. The authors say inherited variation in these genes helps explain who develops the disease.
Catalog record
| CREATOR | Ruisha Tu, Dunjing Zhong, Ping Li, Yongyu Li, Zhuang Chen, Feixiang Hu, Guihong Yuan, Zhaowei Chen, Shuyong Yu, Jian Song |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |