Unraveling the mechanisms of intervertebral disc degeneration: an exploration of the p38 MAPK signaling pathway
Xingmin Zhang, Zilin Zhang, Xiaosong Zou, Yongjie Wang, Jinwei Qi, Song Han, Jingguo Xin, Zhi Zheng, Lin Wei, Tianhui Zhang, Shaokun Zhang · 2024
Read Unraveling the mechanisms of intervertebral disc degeneration: an exploration of the p38 MAPK signaling pathway by Xingmin Zhang, Zilin Zhang, Xiaosong Zou, Yongjie Wang, Jinwei Qi, Song Han, Jingguo Xin, Zhi Zheng, Lin Wei, Tianhui Zhang, Shaokun Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10834758.txt.
Description
Xingmin Zhang and co-authors review a signaling path in worn spinal discs in this paper. Their text is dated 2023, one year earlier than the catalog year shown for the entry. Disc wear is a main cause of low back pain and brings heavy costs to patients and health systems.
The path they review touches nearly every step of disc decay. It feeds swelling, breaks down the disc's support matrix, and drives cell death, aging, and stress harm. Current care mostly eases symptoms rather than halting the decay itself. The authors argue the path is a strong drug target and map what is known about its roles. They close by pointing to gaps that targeted treatment work must fill.
Catalog record
| CREATOR | Xingmin Zhang, Zilin Zhang, Xiaosong Zou, Yongjie Wang, Jinwei Qi, Song Han, Jingguo Xin, Zhi Zheng, Lin Wei, Tianhui Zhang, Shaokun Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |