The prevalence of off-label use and supratherapeutic blood levels of outpatient psychotropic medication in suicidal adolescents
Isabel Hach, Thomas Bertsch, Patrick Nonell · 2024
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Description
Hach, Bertsch, and Nonell published in twenty twenty-four a study of psychiatric drug use in suicidal teenagers. Few psychiatric drugs are approved for adolescents, so off-label use is common. The team checked urine and blood samples from teens admitted for acute suicidality. Samples reflected the drugs they took as outpatients before admission. More than two hundred cases were included, most of them girls.
Over half the teens took at least one prescribed psychiatric drug. Off-label use was far more common for one drug class than for antidepressants. Depressed teens were more often treated within approved labels than teens with stress disorders. Girls showed high drug blood levels much more often than boys. The authors urge blood-level checks to improve safety. They also call for more real-world evidence in this age group.
Catalog record
| CREATOR | Isabel Hach, Thomas Bertsch, Patrick Nonell |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |