Exendin-4 affects calcium signalling predominantly during activation and activity of beta cell networks in acute mouse pancreas tissue slices
Eva Paradiž Leitgeb, Jasmina Kerčmar, Lidija Križančić Bombek, Vilijem Pohorec, Maša Skelin Klemen, Marjan Slak Rupnik, Marko Gosak, Jurij Dolenšek, Andraž Stožer · 2024
Read Exendin-4 affects calcium signalling predominantly during activation and activity of beta cell networks in acute mouse pancreas tissue slices by Eva Paradiž Leitgeb, Jasmina Kerčmar, Lidija Križančić Bombek, Vilijem Pohorec, Maša Skelin Klemen, Marjan Slak Rupnik, Marko Gosak, Jurij Dolenšek, Andraž Stožer (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10826511.txt.
Description
Eva Paradiž Leitgeb and co-authors watch how a diabetes drug cousin stirs insulin-making cells, in a 2023 study. The compound, exendin-4, mimics a gut hormone that boosts insulin release. The team filmed calcium signals, the cells' inner trigger, across whole networks of beta cells in mouse pancreas slices.
At low sugar, the compound woke about a quarter of the cells. With strong sugar, cells switched on faster, reached half strength in half the time, and stayed active longer. Their calcium waves also grew more regular, most of all early on. The study maps how the drug shapes teamwork among beta cells, not just single cells. That network view may help refine drugs that nudge insulin release.
Catalog record
| CREATOR | Eva Paradiž Leitgeb, Jasmina Kerčmar, Lidija Križančić Bombek, Vilijem Pohorec, Maša Skelin Klemen, Marjan Slak Rupnik, Marko Gosak, Jurij Dolenšek, Andraž Stožer |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |