Antifungal activity of eumelanin-inspired indoylenepheyleneethynylene against Cryptococcus neoformans
Brittney N. Conn, Jacob A. Lieberman, Priscilla Chatman, Kaitlyn Cotton, Martha A. Essandoh, Mohammad Ebqa’ai, Toby L. Nelson, Karen L. Wozniak · 2024
Read Antifungal activity of eumelanin-inspired indoylenepheyleneethynylene against Cryptococcus neoformans by Brittney N. Conn, Jacob A. Lieberman, Priscilla Chatman, Kaitlyn Cotton, Martha A. Essandoh, Mohammad Ebqa’ai, Toby L. Nelson, Karen L. Wozniak (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10826398.txt.
Description
Brittney Conn and seven co-authors tested in 2023 a pigment-inspired compound against a fungus that causes meningitis in people with weak immune systems. The fungus kills over one hundred thousand people a year, and current drugs are few and weakening. The compound had already shown power against several bacteria, including a drug-resistant staph.
The team tried it on the standard lab strain of the fungus and on more strains besides. Lab tests checked whether the compound slows or kills the fungus and at what doses. A new chemical family with real antifungal action would widen a very short list of options for a deadly infection.
Catalog record
| CREATOR | Brittney N. Conn, Jacob A. Lieberman, Priscilla Chatman, Kaitlyn Cotton, Martha A. Essandoh, Mohammad Ebqa’ai, Toby L. Nelson, Karen L. Wozniak |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |