Dynamic changes in the migratory microbial components of colon tissue during different periods of sepsis in an LPS-induced rat model
Hao Xu, Jia You, Wenqin He, Lingpeng Pei, Yue Han, Xueer Wang, Zhigang Tian, Xiwei Zheng, Enqi Wu, Yaqin Ling · 2024
Read Dynamic changes in the migratory microbial components of colon tissue during different periods of sepsis in an LPS-induced rat model by Hao Xu, Jia You, Wenqin He, Lingpeng Pei, Yue Han, Xueer Wang, Zhigang Tian, Xiwei Zheng, Enqi Wu, Yaqin Ling (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10822926.txt.
Description
Hao Xu and nine co-authors track bacteria physically migrating into colon tissue during sepsis in rats, and find the source changes with time. Bacterial translocation worsens gut injury in sepsis, but which microbes arrive when was unclear. Animals received a bacterial toxin injection and were sampled at twelve and forty-eight hours.
Source-tracking analysis showed colon tissue microbes shifting dynamically after the insult. Early arrivals came mainly from the colon's own contents. By forty-eight hours, the newcomers predominantly traced to lung tissue, an unexpected gut-lung relay. The migrants correlated with blood indicators and with the resident colon community's composition and function. The study reframes translocation as a staged, multi-organ process rather than one leak.
Catalog record
| CREATOR | Hao Xu, Jia You, Wenqin He, Lingpeng Pei, Yue Han, Xueer Wang, Zhigang Tian, Xiwei Zheng, Enqi Wu, Yaqin Ling |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |