Activated microglia release β−galactosidase that promotes inflammatory neurodegeneration
Emily J. A. Kitchener, Jacob M. Dundee, Guy C. Brown · 2024
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Description
Emily Kitchener and co-authors show that brain immune cells release an enzyme that itself drives nerve damage in a 2024 paper. The enzyme, long used as a marker of aged cells, clears sugar tags from proteins and fats. Microglia, the brain resident guards, raise it when inflamed or aged.
Inflamed microglia moved the enzyme to their surface and shed it into their surroundings. Adding it to mixed brain cultures woke microglia and killed neurons through them. Blocking the enzyme curbed inflammation and neuron loss after a bacterial trigger. The marker, it turns out, is also an actor worth targeting.
Catalog record
| CREATOR | Emily J. A. Kitchener, Jacob M. Dundee, Guy C. Brown |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |