Dissecting EXP2 sequence requirements for protein export in malaria parasites
Ethan L. Pitman, Natalie A. Counihan, Joyanta K. Modak, Mrittika Chowdury, Paul R. Gilson, Chaille T. Webb, Tania F. de Koning-Ward · 2024
Read Dissecting EXP2 sequence requirements for protein export in malaria parasites by Ethan L. Pitman, Natalie A. Counihan, Joyanta K. Modak, Mrittika Chowdury, Paul R. Gilson, Chaille T. Webb, Tania F. de Koning-Ward (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10811066.txt.
Description
Pitman and co-authors dissect a pore protein that malaria parasites use twice in a 2023 study. The record's own head dates the work to 2023. The protein, EXP2, forms a food pore in the parasite's home membrane and also anchors the export machine that ships proteins into the host cell. The team swapped in cut and hybrid versions to learn which parts do which job.
A cousin protein from a related parasite could not fill the export role, even with EXP2 parts grafted on. The body region of EXP2 proved key for machine assembly. Changing when and how much EXP2 is made hurt survival but not export. The authors say its odd expression pattern lets one protein serve two masters.
Catalog record
| CREATOR | Ethan L. Pitman, Natalie A. Counihan, Joyanta K. Modak, Mrittika Chowdury, Paul R. Gilson, Chaille T. Webb, Tania F. de Koning-Ward |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |