Development and comparison of immunologic assays to detect primary RSV infections in infants
Larry J. Anderson, Samadhan J. Jadhao, Laila Hussaini, Binh Ha, Courtney E. McCracken, Theda Gibson, Inci Yildirim, Jumi Yi, Kathy Stephens, Chelsea Korski, Carol Kao, Heying Sun, Chun Yi Lee, Anna Jaunarajs, Christina A. Rostad, Evan J. Anderson · 2024
Read Development and comparison of immunologic assays to detect primary RSV infections in infants by Larry J. Anderson, Samadhan J. Jadhao, Laila Hussaini, Binh Ha, Courtney E. McCracken, Theda Gibson, Inci Yildirim, Jumi Yi, Kathy Stephens, Chelsea Korski, Carol Kao, Heying Sun, Chun Yi Lee, Anna Jaunarajs, Christina A. Rostad, Evan J. Anderson (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10811012.txt.
Description
Larry Anderson and co-authors built and compared seven lab tests that detect a baby's first infection with respiratory syncytial virus, or RSV. Knowing whether a young child has already met the virus matters for vaccine trials, yet no licensed infant vaccine exists and good tests were lacking. The panel covered four antibody tests, two live-virus neutralization tests, and one immune cell test.
All seven tests repeated well. On blood from children months after a proven infection, the two best antibody tests, using a whole-virus lysate and the viral F protein, caught every case. The cell test also lit up in many babies never exposed to a virus season, possibly from traces of maternal cells. The authors recommend the two antibody tests for studies and trials.
Catalog record
| CREATOR | Larry J. Anderson, Samadhan J. Jadhao, Laila Hussaini, Binh Ha, Courtney E. McCracken, Theda Gibson, Inci Yildirim, Jumi Yi, Kathy Stephens, Chelsea Korski, Carol Kao, Heying Sun, Chun Yi Lee, Anna Jaunarajs, Christina A. Rostad, Evan J. Anderson |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |