Differential expression of slow and fast-repriming tetrodotoxin-sensitive sodium currents in dorsal root ganglion neurons
Zhi-Yong Tan, Bin Wu, Xiaolin Su, You Zhou, Yong-Hua Ji · 2024
Read Differential expression of slow and fast-repriming tetrodotoxin-sensitive sodium currents in dorsal root ganglion neurons by Zhi-Yong Tan, Bin Wu, Xiaolin Su, You Zhou, Yong-Hua Ji (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10808659.txt.
Description
Zhi-Yong Tan and co-authors tease apart two sodium currents in pain-sensing neurons in 2023, a step toward studying one key channel in isolation. That channel, Nav1.7, fires the pain signal, but sibling channels muddy direct study. Working in rat and mouse nerve cells, the team split currents by how fast they recover: slow-repriming and fast-repriming types. Three cell subgroups emerged from the patterns.
Most rat cells carried only the slow type; most mouse cells carried both. A blocker drug hit the slow current unevenly across cells. A chemotherapy drug selectively raised the slow current in one cell class. Simulations tied the channel to lower firing thresholds. The dissection gives pharmacology a cleaner window.
Catalog record
| CREATOR | Zhi-Yong Tan, Bin Wu, Xiaolin Su, You Zhou, Yong-Hua Ji |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |