Utilizing multimodal mass spectrometry imaging for profiling immune cell composition and N-glycosylation across colorectal carcinoma disease progression
Lyndsay E. A. Young, Paul J. Nietert, Rachel Stubler, Caroline G. Kittrell, Grace Grimsley, David N. Lewin, Anand S. Mehta, Chadi Hajar, Katherine Wang, Elizabeth C. O’Quinn, Peggi M. Angel, Kristin Wallace, Richard R. Drake · 2024
Read Utilizing multimodal mass spectrometry imaging for profiling immune cell composition and N-glycosylation across colorectal carcinoma disease progression by Lyndsay E. A. Young, Paul J. Nietert, Rachel Stubler, Caroline G. Kittrell, Grace Grimsley, David N. Lewin, Anand S. Mehta, Chadi Hajar, Katherine Wang, Elizabeth C. O’Quinn, Peggi M. Angel, Kristin Wallace, Richard R. Drake (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10808565.txt.
Description
Colon and rectal cancer often grows slowly from small polyps over ten to fifteen years, and immune cells inside a tumor can help or hinder that growth. A team led by Lyndsay Young maps both immune cells and sugar chains on proteins across the stages of the disease in this study, published in 2023. They use imaging mass spectrometry, a method that reads many molecules in place on thin tissue slices.
The team found nearly one hundred kinds of sugar chains, called N-glycans, across their samples. Healthy tissue held more of one simple class, while cancer tissue shifted toward larger and more branched forms as the disease advanced. The immune cell mix also changed with stage. Such maps could point to early signs of cancer and to new ways of sorting patients by risk.
Catalog record
| CREATOR | Lyndsay E. A. Young, Paul J. Nietert, Rachel Stubler, Caroline G. Kittrell, Grace Grimsley, David N. Lewin, Anand S. Mehta, Chadi Hajar, Katherine Wang, Elizabeth C. O’Quinn, Peggi M. Angel, Kristin Wallace, Richard R. Drake |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |