Examining the function of macrophage oxidative stress response and immune system in glioblastoma multiforme through analysis of single-cell transcriptomics
Jin Xing, Huabao Cai, Zhiheng Lin, Liang Zhao, Hao Xu, Yanbing Song, Zhihan Wang, Chaobo Liu, Guangdong Hu, Jiajie Zheng, Li Ren, Zilong Wei · 2024
Read Examining the function of macrophage oxidative stress response and immune system in glioblastoma multiforme through analysis of single-cell transcriptomics by Jin Xing, Huabao Cai, Zhiheng Lin, Liang Zhao, Hao Xu, Yanbing Song, Zhihan Wang, Chaobo Liu, Guangdong Hu, Jiajie Zheng, Li Ren, Zilong Wei (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10808540.txt.
Description
Glioblastoma tumors teem with macrophages, immune cells that can either fight the cancer or shelter it. Jin Xing and co-authors dissected in 2023 single-cell data from tumor cores and edges to learn which role dominates.
Macrophages showed the strongest oxidative stress responses of any cell group and sat at the hub of signaling traffic, largely through one molecular handshake. The pattern suggested they drift from an attack state toward a healing state that suppresses immunity. Two genes tied to macrophages predicted patient outlook. One, MANBA, seemed to restrain the attacking state, and lab tests confirmed it helps the tumor grow and spread.
Catalog record
| CREATOR | Jin Xing, Huabao Cai, Zhiheng Lin, Liang Zhao, Hao Xu, Yanbing Song, Zhihan Wang, Chaobo Liu, Guangdong Hu, Jiajie Zheng, Li Ren, Zilong Wei |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |