Evaluation of proline-rich antimicrobial peptides as potential lead structures for novel antimycotics against Cryptococcus neoformans
Alexandra Brakel, Thomas Grochow, Stefanie Fritsche, Daniel Knappe, Andor Krizsan, Simone A. Fietz, Gottfried Alber, Ralf Hoffmann, Uwe Müller · 2024
Read Evaluation of proline-rich antimicrobial peptides as potential lead structures for novel antimycotics against Cryptococcus neoformans by Alexandra Brakel, Thomas Grochow, Stefanie Fritsche, Daniel Knappe, Andor Krizsan, Simone A. Fietz, Gottfried Alber, Ralf Hoffmann, Uwe Müller (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10800876.txt.
Description
Alexandra Brakel and co-authors present a study, published in 2023, on insect peptides as possible new drugs against a deadly fungal infection. The fungus strikes people with weak immune systems and kills many each year, mostly in poorer countries. Standard drugs are few and can cause harsh side effects, so fresh options are needed.
The team screened twenty antimicrobial peptides, many drawn from insects and rich in one building block. Several well-known peptides were included, plus a mammal peptide for comparison. Against three strains of the fungus, the best peptides stopped growth at low doses. Their low toxicity in past animal work adds to their promise as drug leads.
Catalog record
| CREATOR | Alexandra Brakel, Thomas Grochow, Stefanie Fritsche, Daniel Knappe, Andor Krizsan, Simone A. Fietz, Gottfried Alber, Ralf Hoffmann, Uwe Müller |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |