Pan-cancer Analysis Identifies AIMP2 as a Potential Biomarker for Breast Cancer
Jie Qiu, Tao Zhou, Danhong Wang, Weimin Hong, Da Qian, Xuli Meng, Xiaozhen Liu · 2023
Read Pan-cancer Analysis Identifies AIMP2 as a Potential Biomarker for Breast Cancer by Jie Qiu, Tao Zhou, Danhong Wang, Weimin Hong, Da Qian, Xuli Meng, Xiaozhen Liu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10790333.txt.
Description
A helper protein named AIMP2, part of the cell's protein-building crew, keeps turning up at odd levels in tumors. Jie Qiu and co-authors ran in 2023 a pan-cancer sweep across the big public datasets. They compared its levels in tumor and normal tissue. They also tied them to stage, survival, and the immune cells inside tumors. The protein ran high in twenty-four cancer types.
High levels spelled worse survival in five cancers. The team then zeroed in on breast cancer: silencing the gene in lab cells slowed their growth and spread. They nominate AIMP2 as a prognostic marker and possible target, above all for breast cancer.
Catalog record
| CREATOR | Jie Qiu, Tao Zhou, Danhong Wang, Weimin Hong, Da Qian, Xuli Meng, Xiaozhen Liu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |