Diabetes mellitus and prostate cancer risk: A mendelian randomization analysis
Jian-Xu Yuan, Qing Jiang, Sheng-Jie Yu · 2023
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Description
Yuan, Jiang, and Yu ask whether diabetes itself raises the risk of prostate cancer, using genetics as a natural experiment, in this 2023 study. Observational reports on the pair have disagreed for years. Mendelian randomization uses inherited variants, set at conception, to cut through the usual confounding.
Data came from a large public genome database. Three estimation methods were run, with sensitivity checks on each. All pointed the same way: genetic liability to diabetes acted as a small independent risk factor for prostate cancer. The headline odds ratio sat just above one, at 1.018. The authors read the link as real but modest. They suggest metabolic care belongs in prostate risk talks.
Catalog record
| CREATOR | Jian-Xu Yuan, Qing Jiang, Sheng-Jie Yu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |