Phoenixin-20 ameliorates Sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of the PKA/CREB signaling
Jing Zhang, Zhao Wang, Kun Cong, Jun Qi, Lining Sun · 2023
Read Phoenixin-20 ameliorates Sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of the PKA/CREB signaling by Jing Zhang, Zhao Wang, Kun Cong, Jun Qi, Lining Sun (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10781492.txt.
Description
Jing Zhang, Zhao Wang, Kun Cong, and a wider team wrote this research paper, published in 2023. It tests a small peptide, phoenixin-20, as a shield against the fuzzy thinking that can follow surgery under the anesthetic sevoflurane.
Post-operative confusion is common and poorly understood, with oxidative stress and inflammation suspected. Rats breathed the anesthetic, with or without a week of peptide doses. Untreated rats took longer to escape a water maze and remembered the target zone worse. Their hippocampus, the brain's memory hub, showed more damage and cell death. The peptide largely erased those deficits. It also calmed inflammation and oxidative stress in the tissue. Brain support factors and a key memory signaling chain fell after anesthesia, and the peptide restored them. The authors propose the peptide as a candidate guard for patients' minds.
Catalog record
| CREATOR | Jing Zhang, Zhao Wang, Kun Cong, Jun Qi, Lining Sun |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |