Prognostic value and immune regulatory role of dynamin 1-like in lung adenocarcinoma
Wenping Song, Xuan Wu, Shuai Wang, Martin P. Barr, María Rodríguez, In-Jae Oh, Yingxi Wu, Ding Li · 2023
Read Prognostic value and immune regulatory role of dynamin 1-like in lung adenocarcinoma by Wenping Song, Xuan Wu, Shuai Wang, Martin P. Barr, María Rodríguez, In-Jae Oh, Yingxi Wu, Ding Li (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10775004.txt.
Description
Wenping Song and seven co-authors wrote this 2023 study on a gene that may drive the most common form of lung cancer. The gene makes a protein that splits mitochondria, the cell's power plants, and splitting is known to feed tumor growth. The team checked how active the gene is in lung adenocarcinoma and whether its level tracks patient outcomes or immune cell traffic in tumors.
Across public databases, the gene ran hotter in tumors than in healthy tissue, and high levels marked patients with worse survival. Its activity also rose and fell with many immune cell signals, painting it as part of the tumor's immune landscape. In lab dishes, boosting the gene made cancer cells grow and migrate faster. The authors propose the gene as both a warning marker and a possible drug target. They note the exact mechanism still needs pinning down.
Catalog record
| CREATOR | Wenping Song, Xuan Wu, Shuai Wang, Martin P. Barr, María Rodríguez, In-Jae Oh, Yingxi Wu, Ding Li |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |