Copine 1 predicts poor clinical outcomes by promoting M2 macrophage activation in ovarian cancer
Bo Sheng, Bo Zhao, Yue Dong, Jiamin Zhang, Suni Wu, Huihui Ji, Xueqiong Zhu · 2023
Read Copine 1 predicts poor clinical outcomes by promoting M2 macrophage activation in ovarian cancer by Bo Sheng, Bo Zhao, Yue Dong, Jiamin Zhang, Suni Wu, Huihui Ji, Xueqiong Zhu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10773812.txt.
Description
Bo Sheng and a team of co-authors pin a membrane protein to poor outcomes in ovarian cancer, in a paper dated twenty twenty-three. Copine 1 runs high in these tumors, often by gene copying. The team checked its levels, its tie to survival, and its work in cells and mice.
High levels tracked shorter survival. Raising the protein sped tumor cell growth, spread, and mouse tumor growth; cutting it did the reverse. The protein also pushed immune macrophages toward the tumor-helping M2 state, lifting its marker signals. The authors name Copine 1 a warning sign and possible target.
Catalog record
| CREATOR | Bo Sheng, Bo Zhao, Yue Dong, Jiamin Zhang, Suni Wu, Huihui Ji, Xueqiong Zhu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |