Ketogenic diet therapy for pediatric epilepsy is associated with alterations in the human gut microbiome that confer seizure resistance in mice
Gregory R Lum, Sung Min Ha, Christine A Olson, Montgomery Blencowe, Jorge Paramo, Beck Reyes, Joyce H Matsumoto, Xia Yang, Elaine Y Hsiao · 2023
Read Ketogenic diet therapy for pediatric epilepsy is associated with alterations in the human gut microbiome that confer seizure resistance in mice by Gregory R Lum, Sung Min Ha, Christine A Olson, Montgomery Blencowe, Jorge Paramo, Beck Reyes, Joyce H Matsumoto, Xia Yang, Elaine Y Hsiao (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10769314.txt.
Description
Gregory R Lum and co-authors tested whether the gut changes caused by a ketogenic diet in children with epilepsy can themselves protect against seizures, in a study published in 2023. The high-fat diet is a known therapy for hard-to-treat childhood epilepsy, and animal work had tied its power partly to gut microbes.
Children on the diet showed altered gut microbe function. When those diet-shaped microbes were transplanted into mice, the mice resisted seizures better than mice given the same children's pre-diet microbes. Shared chemical signatures linked fat burning and amino acid handling to the effect. The transplanted mice also showed changed gene activity in a memory region of the brain, in pathways tied to energy and to human epilepsy genes.
Catalog record
| CREATOR | Gregory R Lum, Sung Min Ha, Christine A Olson, Montgomery Blencowe, Jorge Paramo, Beck Reyes, Joyce H Matsumoto, Xia Yang, Elaine Y Hsiao |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |