T cell-mediated curation and restructuring of tumor tissue coordinates an effective immune response
John W Hickey, Maximillian Haist, Nina Horowitz, Chiara Caraccio, Yuqi Tan, Andrew J Rech, Marc-Andrea Baertsch, Xavier Rovira-Clavé, Bokai Zhu, Gustavo Vazquez, Graham Barlow, Eran Agmon, Yury Goltsev, John B Sunwoo, Markus Covert, Garry P Nolan · 2023
Read T cell-mediated curation and restructuring of tumor tissue coordinates an effective immune response by John W Hickey, Maximillian Haist, Nina Horowitz, Chiara Caraccio, Yuqi Tan, Andrew J Rech, Marc-Andrea Baertsch, Xavier Rovira-Clavé, Bokai Zhu, Gustavo Vazquez, Graham Barlow, Eran Agmon, Yury Goltsev, John B Sunwoo, Markus Covert, Garry P Nolan (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10765317.txt.
Description
Hickey and co-authors map how T cells reshape tumor tissue over time during immune therapy. T cells that target tumors both respond to and create local neighborhoods. The team used layered imaging in a mouse melanoma model of cell therapy. Human melanoma samples from checkpoint drug patients were studied too. Maps revealed shifting zones of immune cells around tumor cells. Inflamed neighborhoods clustered near CD8 T cells.
Strong responses showed inflamed tumor-T cell zones ringed by dense immune zones. Weak responses leaned toward calming signals instead. T cells sat along a gradient of neighborhoods that mirrors response steps. The work frames therapy success as a spatial story, not just a cell count.
Catalog record
| CREATOR | John W Hickey, Maximillian Haist, Nina Horowitz, Chiara Caraccio, Yuqi Tan, Andrew J Rech, Marc-Andrea Baertsch, Xavier Rovira-Clavé, Bokai Zhu, Gustavo Vazquez, Graham Barlow, Eran Agmon, Yury Goltsev, John B Sunwoo, Markus Covert, Garry P Nolan |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |