Apolipoprotein E Genetic Variant and Blood Lipid Responses to Plant Sterols: A Systematic Review and Pooled Analysis of Clinical Trials
Suhad Abumweis, Lara Alzyoud, Sarah Alqadi · 2023
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Description
Suhad Abumweis, Lara Alzyoud, and Sarah Alqadi present a 2023 pooled review of whether a gene variant changes how plant sterols cut cholesterol. Plant sterols and stanols lower blood cholesterol, a fact used in foods and pills. The apolipoprotein E gene comes in forms that may tune that gain.
Trials were pulled from the Cochrane shelf, eleven papers from over three thousand hits. Pooled math set each gene group's lipid shifts side by side. The E3 group cut bad cholesterol by a quarter unit, more than the E2 and E4 groups. In E4 carriers, dose and span of dosing drove a larger cut. Age and health state were also weighed as tuners of the effect.
Catalog record
| CREATOR | Suhad Abumweis, Lara Alzyoud, Sarah Alqadi |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |