Coadministration of Lactulose with Probiotics Ameliorates Loperamide-Induced Constipation in Mice
Chun Woong Park, Jihyun Lee, Yang Hee Hong, Young Suk Kim, Hyung Joo Suh, Yejin Ahn · 2023
Read Coadministration of Lactulose with Probiotics Ameliorates Loperamide-Induced Constipation in Mice by Chun Woong Park, Jihyun Lee, Yang Hee Hong, Young Suk Kim, Hyung Joo Suh, Yejin Ahn (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10764220.txt.
Description
Park and co-authors test whether pairing a mild laxative sugar with probiotic strains eases constipation better than either alone, in this 2023 mouse study. Constipation was triggered with a drug that slows the gut. The team then tracked stool traits, gut transit speed, and gut chemistry.
Two partners stood out: a Bacillus strain and a yeast strain, each combined with lactulose. Both mixes restored stool number and water content and sped transit beyond the untreated pattern. They also raised levels of helpful short-chain fatty acids in stool more than lactulose alone. A mix with magnesium hydroxide helped as well. The authors credit the acid boost for much of the relief.
Catalog record
| CREATOR | Chun Woong Park, Jihyun Lee, Yang Hee Hong, Young Suk Kim, Hyung Joo Suh, Yejin Ahn |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |