A critical role for iron and zinc homeostatic systems in the evolutionary adaptation of Escherichia coli to metal restriction
Joy R. Paterson, Joshua M. Wadsworth, Ping Hu, Gary J. Sharples · 2023
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Description
Joy R Paterson and three co-authors report a 2023 study of how E coli bacteria adapt when metals are scarce. Hosts fight infection in part by locking metals away. The team grew the bacteria with two chelators, compounds that grab metals, each cutting iron, manganese, and zinc in its own way.
After growth at low chelator levels, mutant strains were sequenced. One change raised output of a zinc helper gene and drove resistance to the first chelator. A second change lifted an iron uptake path and helped against the other chelator, once parts were boosted. A third change kept the growth fluid from turning acid. The study maps escape routes bacteria may use against host metal defenses.
Catalog record
| CREATOR | Joy R. Paterson, Joshua M. Wadsworth, Ping Hu, Gary J. Sharples |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |