Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment
Ejlal Abu-El-Rub, Fatimah Almahasneh, Ramada R Khasawneh, Ayman Alzu'bi, Doaa Ghorab, Rawan Almazari, Huthaifa Magableh, Ahmad Sanajleh, Haitham Shlool, Mohammad Mazari, Noor S Bader, Joud Al-Momani · 2023
Read Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment by Ejlal Abu-El-Rub, Fatimah Almahasneh, Ramada R Khasawneh, Ayman Alzu'bi, Doaa Ghorab, Rawan Almazari, Huthaifa Magableh, Ahmad Sanajleh, Haitham Shlool, Mohammad Mazari, Noor S Bader, Joud Al-Momani (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10762524.txt.
Description
Stem cells meant to repair diabetic tissue die quickly in the very sugar-rich environment they are sent to fix. Ejlal Abu-El-Rub and eleven co-authors asked what the sugar does to them, in a 2023 study. They grew human fat-derived mesenchymal stem cells for seven days in normal or high glucose.
The high-glucose cells lost viability and showed disturbed mitochondria, the cell's power plants, in their splitting and fusing balance. Signs of programmed cell death rose. Protein measurements traced a signaling chain, through PI3K, TSC1, and mTOR, that links nutrient sensing to the damage. The authors argue the transplant problem is partly a preparation problem: cells raised or shielded against glucose stress before delivery might survive long enough in diabetic tissue to do their repair work.
Catalog record
| CREATOR | Ejlal Abu-El-Rub, Fatimah Almahasneh, Ramada R Khasawneh, Ayman Alzu'bi, Doaa Ghorab, Rawan Almazari, Huthaifa Magableh, Ahmad Sanajleh, Haitham Shlool, Mohammad Mazari, Noor S Bader, Joud Al-Momani |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |